{"id":1809,"date":"2020-10-06T06:06:53","date_gmt":"2020-10-06T06:06:53","guid":{"rendered":"https:\/\/cbdnauda.lt\/?p=1809"},"modified":"2020-10-06T06:39:15","modified_gmt":"2020-10-06T06:39:15","slug":"kanapiu-junginys-peles-apsaugojo-nuo-storosios-zarnos-vezio","status":"publish","type":"post","link":"https:\/\/cbdnauda.lt\/kanapiu-junginys-peles-apsaugojo-nuo-storosios-zarnos-vezio\/","title":{"rendered":"Kanapi\u0173 junginys peles apsaugojo nuo storosios \u017earnos v\u0117\u017eio"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_61 counter-flat ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<p class=\"ez-toc-title\">Straipsnio turinys<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-663b0a0d52d69\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"ez-toc-cssicon\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-663b0a0d52d69\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/cbdnauda.lt\/kanapiu-junginys-peles-apsaugojo-nuo-storosios-zarnos-vezio\/#THC_gali_uzkirsti_kelia_uzdegimui\" title=\"THC gali u\u017ekirsti keli\u0105 u\u017edegimui\">THC gali u\u017ekirsti keli\u0105 u\u017edegimui<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/cbdnauda.lt\/kanapiu-junginys-peles-apsaugojo-nuo-storosios-zarnos-vezio\/#Veiksmo_mechanizmas\" title=\"Veiksmo mechanizmas\">Veiksmo mechanizmas<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/cbdnauda.lt\/kanapiu-junginys-peles-apsaugojo-nuo-storosios-zarnos-vezio\/#Tyrimo_apribojimai\" title=\"Tyrimo apribojimai\">Tyrimo apribojimai<\/a><\/li><\/ul><\/nav><\/div>\n<p>U\u017edegimin\u0117 \u017earnyno liga (IBD) rei\u0161kia l\u0117tini\u0173 lig\u0173 grup\u0119, veikian\u010di\u0105 gaubtin\u0119 ir plon\u0105j\u0105 \u017earn\u0105. Jie apima Krono lig\u0105 ir <em>opin\u012f kolit\u0105<\/em>.<\/p>\n<p>IBD normos <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4020403\/\" target=\"_blank\" rel=\"noopener\">smarkiai padid\u0117jo<\/a> 20-ojo am\u017eiaus antroje pus\u0117je, o kai kuriose \u0161alyse jos ir <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0016508519300216\" target=\"_blank\" rel=\"noopener\">toliau auga<\/a>. I\u0161 ties\u0173, 2015 m. JAV apie <a href=\"https:\/\/www.cdc.gov\/ibd\/data-statistics.htm\" target=\"_blank\" rel=\"noopener\">3 milijonai suaugusi\u0173j\u0173<\/a> gavo IBD diagnoz\u0119.<\/p>\n<p>Neseniai i\u0161aug\u0119s \u0161i\u0173 s\u0105lyg\u0173 paplitimas rodo, kad ka\u017ekas, kaip mes gyvename, gali paskatinti \u0161ios ligos vystym\u0105si. Pavyzd\u017eiui, mokslininkai teig\u0117, kad padid\u0117j\u0119s <a href=\"https:\/\/journals.lww.com\/ajg\/Abstract\/2010\/10000\/Animal_Protein_Intake_and_Risk_of_Inflammatory.15.aspx\" target=\"_blank\" rel=\"noopener\">m\u0117sos vartojimas<\/a> gali b\u016bti veiksnys.<\/p>\n<p>Did\u0117jan\u010dios diagnoz\u0117s kelia ypating\u0105 susir\u016bpinim\u0105, nes IBD sergantiems \u017emon\u0117ms yra didesn\u0117 rizika susirgti storosios \u017earnos v\u0117\u017eiu &#8211; liga, kurios vidutinis 5 met\u0173 i\u0161gyvenamumas yra 63%. Storosios \u017earnos v\u0117\u017eys taip pat vis da\u017eniau pasitaiko tarp jaun\u0173 \u017emoni\u0173.<\/p>\n<p>Naujame \u017eurnale \u201e<a href=\"https:\/\/www.cell.com\/iscience\/fulltext\/S2589-0042(20)30696-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2589004220306969%3Fshowall%3Dtrue\" target=\"_blank\" rel=\"noopener\">iScience<\/a>\u201c pasirod\u017eiusiame tyrime Kolumbijos Piet\u0173 Karolinos universiteto (USC) mokslininkai i\u0161band\u0117 nauj\u0105 po\u017ei\u016br\u012f \u012f storosios \u017earnos v\u0117\u017eio prevencij\u0105.<\/p>\n<p>Jie peles gyd\u0117 kanapi\u0173 junginiu <a href=\"https:\/\/cbdnauda.lt\/thc-tetrahidrokanabinolis-kas-tai\/\">THC<\/a>, kuris veiksmingai u\u017ekirto keli\u0105 u\u017edegimui ir sustabd\u0117 storosios \u017earnos v\u0117\u017eio vystym\u0105si.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"THC_gali_uzkirsti_kelia_uzdegimui\"><\/span>THC gali u\u017ekirsti keli\u0105 u\u017edegimui<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Mokslininkai tyrim\u0105 grind\u0117 su kolitu susijusio storosios \u017earnos v\u0117\u017eio peli\u0173 modeliais. Kai kurias peles jie gyd\u0117 THC, o kontrolin\u0117s grup\u0117s pel\u0117s gavo tik ne\u0161ikl\u012f, kuris yra pana\u0161us \u012f placeb\u0105.<\/p>\n<p><strong>Tyrimo pabaigoje THC gavusios pel\u0117s, skirtingai nei kontrolin\u0117 grup\u0117, neparod\u0117 navik\u0173. THC grup\u0117s pel\u0117ms taip pat buvo \u017eymiai ma\u017eiau storosios \u017earnos u\u017edegimo, kuris yra IBD simptomas.<\/strong><\/p>\n<blockquote class=\"pullquote align-center\"><p>\u201eTai, kad mums pavyko parodyti, jog gydymas THC u\u017ekerta keli\u0105 storosios \u017earnos u\u017edegimui ir tuo pa\u010diu slopina storosios \u017earnos v\u0117\u017eio vystym\u0105si, patvirtina nuomon\u0119, kad u\u017edegimas ir storosios \u017earnos v\u0117\u017eys yra glaud\u017eiai susij\u0119\u201c, &#8211; ai\u0161kina vyresniojo tyrimo autorius <em>dr. Prakashas Nagarkatti.<\/em><\/p><\/blockquote>\n<p>Tyr\u0117jai toliau tyr\u0117, kaip THC gali tur\u0117ti \u0161\u012f <a href=\"https:\/\/cbdnauda.lt\/marihuanos-poveikis-organizmui\/\">poveik\u012f<\/a>. Jie nustat\u0117, kad junginys jungiasi prie 2 tipo <a href=\"https:\/\/cbdnauda.lt\/kanabinoidai-kas-tai\/\">kanabinoidini\u0173<\/a> receptori\u0173 (CB2), kuris yra ekspresuojamas imunin\u0117se l\u0105stel\u0117se ir visoje vir\u0161kinimo sistemoje.<\/p>\n<p>\u201eTaigi [\u017emon\u0117ms], kuriems yra didesn\u0117 rizika susirgti storosios \u017earnos v\u0117\u017eiu, THC ar kiti prie\u0161u\u017edegiminiai vaistai gali b\u016bti naudingi\u201c, &#8211; priduria <em>Dr. Nagarkatti.<\/em><\/p>\n<h3><span class=\"ez-toc-section\" id=\"Veiksmo_mechanizmas\"><\/span><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-1811\" src=\"https:\/\/cbdnauda.lt\/wp-content\/uploads\/2020\/10\/opinis-kolitas-kanapiu-gydymas.jpg\" alt=\"opinis kolitas kanapiu gydymas\" width=\"939\" height=\"470\" title=\"\" srcset=\"https:\/\/cbdnauda.lt\/wp-content\/uploads\/2020\/10\/opinis-kolitas-kanapiu-gydymas.jpg 939w, https:\/\/cbdnauda.lt\/wp-content\/uploads\/2020\/10\/opinis-kolitas-kanapiu-gydymas-300x150.jpg 300w, https:\/\/cbdnauda.lt\/wp-content\/uploads\/2020\/10\/opinis-kolitas-kanapiu-gydymas-768x384.jpg 768w, https:\/\/cbdnauda.lt\/wp-content\/uploads\/2020\/10\/opinis-kolitas-kanapiu-gydymas-360x180.jpg 360w, https:\/\/cbdnauda.lt\/wp-content\/uploads\/2020\/10\/opinis-kolitas-kanapiu-gydymas-750x375.jpg 750w\" sizes=\"(max-width: 939px) 100vw, 939px\" \/>Veiksmo mechanizmas<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>CB2 receptoriai moduliuoja \u017earnyno u\u017edegim\u0105, ir mokslininkai anks\u010diau juos nustat\u0117 kaip galim\u0105 IBD terapin\u012f taikin\u012f. \u0160is tyrimas pateikia verting\u0105 \u0161ios id\u0117jos koncepcijos \u012frodym\u0105.<\/p>\n<div class=\"alert alert-warning\"><strong>!<\/strong> \u201e[C] junginiai, kurie aktyvina CB2 ir nesukelia psichoaktyvaus poveikio, gali b\u016bti naudingi siekiant u\u017ekirsti keli\u0105 IBD ir gaubtin\u0117s \u017earnos v\u0117\u017eiui.\u201c<\/div>\n<blockquote class=\"pullquote align-center\"><p>&#8211; Tyrimo bendraautorius Dr. Mitzi Nagarkatti, USC V\u0117\u017eio vaist\u0173 atradimo centro pirmininkas<\/p><\/blockquote>\n<p>Ateityje pastangos bus sutelktos kuriant ne psichoaktyvius junginius, nukreiptus \u012f CB2 receptorius, kad b\u016bt\u0173 sukeliamas pana\u0161us poveikis.<\/p>\n<p>Tyrimas taip pat pateikia i\u0161sami\u0105 mechanistin\u0119 informacij\u0105 apie tai, kaip veikia kelias, parodydamas, kad <strong>THC prisijungimas prie CB2 receptori\u0173 sukelia prie\u0161u\u017edegimin\u012f proces\u0105<\/strong>.<\/p>\n<p>Tod\u0117l \u017earnyno l\u0105stel\u0117s re\u010diau i\u0161skiria u\u017edegim\u0105 skatinan\u010dias molekules, o i\u0161skiria prie\u0161u\u017edegimines molekules. \u0160ios molekul\u0117s verbuoja reguliuojamas T l\u0105steles, kurios yra tam tikros r\u016b\u0161ies imunin\u0117s l\u0105stel\u0117s, kurios gali pad\u0117ti i\u0161spr\u0119sti u\u017edegim\u0105 ir apsaugoti nuo v\u0117\u017eio.<\/p>\n<p>\u0160ios i\u0161vados skatina biologin\u012f IBD supratim\u0105 ir bus naudingos b\u016bsimoms vaist\u0173 k\u016brimo pastangoms.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Tyrimo_apribojimai\"><\/span>Tyrimo apribojimai<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Svarbu pa\u017eym\u0117ti, kad \u0161is tyrimas rodo <strong>prevencin\u012f<\/strong>, bet ne gydom\u0105j\u012f poveik\u012f. Tai rei\u0161kia, kad n\u0117ra duomen\u0173, leid\u017eian\u010di\u0173 manyti, kad THC ar kiti CB2 agonistai gal\u0117t\u0173 gydyti IBD ar storosios \u017earnos v\u0117\u017e\u012f.<\/p>\n<p>\u0160iame tyrime taip pat nerekomenduojama vartoti kanapi\u0173 siekiant i\u0161vengti storosios \u017earnos v\u0117\u017eio. Tai tik rodo, kad ne psichoaktyvi\u0173 jungini\u0173, nukreipt\u0173 \u012f CB2 receptorius, k\u016brimas gali b\u016bti naudingas \u017emon\u0117ms, sergantiems IBD.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>U\u017edegimin\u0117 \u017earnyno liga (IBD) rei\u0161kia l\u0117tini\u0173 lig\u0173 grup\u0119, veikian\u010di\u0105 gaubtin\u0119 ir plon\u0105j\u0105 \u017earn\u0105. Jie apima Krono lig\u0105 ir opin\u012f kolit\u0105. IBD normos smarkiai padid\u0117jo 20-ojo am\u017eiaus antroje pus\u0117je, o kai kuriose \u0161alyse jos ir toliau auga. I\u0161 ties\u0173, 2015 m. JAV apie 3 milijonai suaugusi\u0173j\u0173 gavo IBD diagnoz\u0119. Neseniai i\u0161aug\u0119s \u0161i\u0173 s\u0105lyg\u0173 paplitimas rodo, kad [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1812,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[420,937],"tags":[],"_links":{"self":[{"href":"https:\/\/cbdnauda.lt\/wp-json\/wp\/v2\/posts\/1809"}],"collection":[{"href":"https:\/\/cbdnauda.lt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cbdnauda.lt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cbdnauda.lt\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cbdnauda.lt\/wp-json\/wp\/v2\/comments?post=1809"}],"version-history":[{"count":0,"href":"https:\/\/cbdnauda.lt\/wp-json\/wp\/v2\/posts\/1809\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cbdnauda.lt\/wp-json\/wp\/v2\/media\/1812"}],"wp:attachment":[{"href":"https:\/\/cbdnauda.lt\/wp-json\/wp\/v2\/media?parent=1809"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cbdnauda.lt\/wp-json\/wp\/v2\/categories?post=1809"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cbdnauda.lt\/wp-json\/wp\/v2\/tags?post=1809"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}